Friday, December 14, 2012

Green Blog: Doctors Urge U.S. to Block Gas Export Terminals

More than 100 physicians urged the Obama administration on Thursday not to approve the construction of liquefied natural gas export terminals until more is known about the health effects of hydraulic fracturing, the drilling process that has opened the way for a big increase in domestic gas production.

A group called Physicians, Scientists and Engineers for Healthy Energy, which conducts research into unconventional natural gas production, organized a petition arguing that exports of natural gas would increase such domestic drilling, known as fracking, exposing more people to chemicals that might damage their health.

The petition, signed by 107 doctors, public health experts, environmental scientists, and academics, cited a growing number of anecdotal reports associating fracking with adverse health risks through human exposure to water, air and soil.

Despite reports that some people living near gas-drilling operations are suffering from respiratory, skin and gastrointestinal ailments, there is no established body of scientific evidence establishing whether fracking contaminates the local environment, the physicians noted.

Until policymakers and public health officials determine whether fracking is dangerous to human health, they argue, the government should not allow the development of the 15 new export terminals that have been proposed by the gas industry. The government has so far approved one export terminal, proposed by Cheniere Energy, in Louisiana.

?There is a paucity of objective, evidence-based epidemiological research,? Dr. Madelon Finkel, a professor of public health at Weill Cornell Medical College in New York City, said during a conference call with reporters.

The petition follows the publication on Dec. 4 of a government study concluding that the economic benefits of LNG exports would outweigh the impacts of the higher domestic prices that may result. The report has encouraged speculation that more projects will be approved.

The demand for exports has arisen from a recent boom in domestic production resulting from the use of fracking in combination with horizontal drilling, which has allowed the industry to exploit vast but shale gas reserves. Energy companies are also lured by sharply higher natural gas prices overseas.

The natural gas industry denies there is any link between fracking and environmental contamination, arguing that the chemicals used to help release gas from shale beds are injected into the ground through multiple layers of steel and concrete and released into the shale beneath thousands of feet of impervious rock.

Dan Whitten, a spokesman for America?s Natural Gas Alliance, dismissed the physicians? concerns.

?There is no basis in fact or science for the assertions made by this group,? Mr. Whitten said in a statement. ?Natural gas is produced safely and responsibly every day, and that production is governed by extensive federal, state and local regulations.?

But Dr. Adam Law, a physician at Cayuga Medical Center in Ithaca, N.Y., said that researchers are finding ?measurable? levels of pollutants from the gas industry in the air and water that are associated with the risk of illness, and that the first studies describing such exposure are entering the medical literature.

Seth Shonkoff, executive director of the physicians? group, said that a current investigation into fracking by the Environmental Protection Agency would not fully establish whether fracking is safe because it is concerned only with its effects on water.

The White House did not immediately respond to a request for comment on the petition.

Source: http://green.blogs.nytimes.com/2012/12/13/doctors-urge-u-s-to-block-gas-export-terminals/?partner=rss&emc=rss

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Small businesses have many resources | TribLIVE


By Chuck Myers

Published: Thursday, December 13, 2012, 12:01?a.m.
Updated 15 hours ago

There?s more support for small business out there than most would think, in the form of business organizations and agencies.

Some small business organizations offer general information and support, while others provide more specialized insights, such as how to apply for a small business loan or tracking expenses. And many of these groups have a presence on the Web.

If you own a small business or are considering creating one, you might find some helpful tips at one of the following sites:

= Association of Small Business Development Centers: Offers measures small businesses can take to ride out an economic downturn. www.asbdc-us.org/Tips_for_an_Economic_Downturn_2.html

= Better Business Bureau: Provides resource library that includes an array of tips geared toward running a business. www.bbb.org/us/Business-Resources/

= National Business Association: Nonprofit organization with an article library dedicated to assisting small business owners. www.nationalbusiness.org/articles

= National Federation of Independent Business: Small business association that offers a variety of tools, tips and guidelines. www.nfib.com/business-resources

= SmartAboutMoney.org: Spotlights eight steps that can help a small business survive. www.smartaboutmoney.org/HowCanIHelpMySmallBusinessSurvive/tabid/745/Default.aspx

= Small Business Administration: Features a small business planner and a wide range of services, including loan and grant information. www.sba.gov

Source: McClatchy-Tribune Information Services

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Source: http://triblive.com/business/headlines/3111295-74/business-www-org

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Thursday, December 13, 2012

Adobe Lightroom 4.3 now available, brings support for Retina displays and more

Adobe Lightroom 43 now available, brings support for Retina displays and more

It's been but a mere few days since Adobe added some much-welcomed Retina support to its Photoshop and Illustrator CS6 apps, but that's not stopping the outfit from coming back with more updates today. This time out, however, it's the creative software giant's Lightroom, which leaves its 4.3 beta stages behind and is now available in full, bringing with it compatibility with high-res screens while developing / viewing pics, RAW image support for about 20 new cameras and a number of bug fixes that should solve issues with the application being unfriendly with some lenses. The new version of Lightroom is up for download now, and you can grab it by checking for updates from within the app or via Adobe's own site.

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Via: TechCrunch

Source: Adobe (PDF)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/EHkALnoVrSI/

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Study paves way to design drugs aimed at multiple protein targets at once

Dec. 12, 2012 ? An international research collaboration led by scientists at the University of North Carolina School of Medicine and the University of Dundee, in the U.K., have developed a way to efficiently and effectively make designer drugs that hit multiple protein targets at once.

This accomplishment, described in the Dec. 13, 2012 issue of the journal Nature, may prove invaluable for developing drugs to treat many common human diseases such as diabetes, high blood pressure, obesity, cancer, schizophrenia, and bi-polar disorder.

These disorders are called complex diseases because each have a number of genetic and non-genetic influences that determine susceptibility, i.e., whether someone will get the disease or not.

"In terms of the genetics of schizophrenia we know there are likely hundreds of different genes that can influence the risk for disease and, because of that, there's likely no single gene and no one drug target that will be useful for treating it, like other common complex diseases," said study co-leader, Brian L. Roth, MD, PhD, Michael J. Hooker Distinguished Professor of Pharmacology in the UNC School of Medicine, professor in the Division of Chemical Biology and Medicinal Chemistry in the UNC Eshelman School of Pharmacy, and director of the National Institute of Mental Health Psychoactive Drug Screening Program.

In complex neuropsychiatric conditions, infectious diseases and cancer, Roth points out that for the past 20 years drug design has been selectively aimed at a single molecular target, but because these are complex diseases, the drugs are often ineffective and thus many never reach the market.

Moreover, a drug that acts on a single targeted protein may interact with many other proteins. These undesired interactions frequently cause toxicity and adverse effects.

"And so the realization has been that perhaps one way forward is to make drugs that hit collections of drug targets simultaneously. This paper provides a way to do that," Roth said.

The new way involves automated drug design by computer that takes advantage of large databases of drug-target interactions. The latter have been made public through Roth's lab at UNC and through other resources.

Basically, the researchers, also co-led by Andrew L. Hopkins, PhD in the Division of Biological Chemistry and Drug Discovery, College of Life Sciences, at the University of Dundee, in Scotland, used the power of computational chemistry to design drug compounds that were then synthesized by chemists, tested in experimental assays and validated in mouse models of human disease.

The study team experimentally tested 800 drug-target predictions of the computationally designed compounds; of these, 75 percent were confirmed in test-tube (in vitro) experiments.

Drug to target engagement also was confirmed in animal models of human disease. In a mouse model of attention deficit hyperactivity disorder (ADHD), mice missing a particular dopamine receptor engage in recurrent aberrant behaviors similar to what is seen in ADHD: distractibility and novelty seeking. "We created a compound that was predicted to prevent those recurrent behaviors and it worked quite well," Roth said.

The researchers then tested the compound in another mouse model where a particular enzyme for a brain neuropeptide is missing. Distractibility and novelty seeking also are behavioral features in these animals. And the drug had the same effect in those mice.

The new drug design process includes ensuring that compounds enter the brain by crossing the blood-brain barrier. These, too, were tested successfully in live animals.

According to Roth, pharmaceutical company chemists had suggested that the objective of a drug hitting multiple targets simultaneously is impossible and unlikely to succeed. "Here we show how to efficiently and effectively make designer drugs that can do that."

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The above story is reprinted from materials provided by University of North Carolina Health Care.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. J?r?my Besnard, Gian Filippo Ruda, Vincent Setola, Keren Abecassis, Ramona M. Rodriguiz, Xi-Ping Huang, Suzanne Norval, Maria F. Sassano, Antony I. Shin, Lauren A. Webster, Frederick R. C. Simeons, Laste Stojanovski, Annik Prat, Nabil G. Seidah, Daniel B. Constam, G. Richard Bickerton, Kevin D. Read, William C. Wetsel, Ian H. Gilbert, Bryan L. Roth, Andrew L. Hopkins. Automated design of ligands to polypharmacological profiles. Nature, 2012; 492 (7428): 215 DOI: 10.1038/nature11691

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/biochemistry/~3/deFlpBdvRVc/121212134058.htm

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Tuesday, December 11, 2012

Why need to seek a good real estate agent in Vancouver ? Welcome ...

Those who are in search of a suitable Vancouver real estate agent to buy or sell property at Vancouver can adopt several methods. Making enquiries with friends and relatives who already had deals there is one of the best methods to find out the good Vancouver realtor. One can have a chat with the realtor to know more about him and also go through the remarks made by his earlier clients. It is very important to assess his knowledge about the real estate market of that place and also he must have the experience of dealing with the type of properties as envisaged by the buyer.

Those who are quite new to Vancouver city or those who could not get a suitable realtor through their friends and relatives can just move around the area of their choice to buy a house. They may come across with numerous ?For Sale? signs. The real estate agency that is with a lot of signs must have thorough knowledge about the locality and the local market. Finding out a Vancouver realtor from Yellow Pages or phone book is another method. A visit to the local office of a Vancouver real estate agent also will be fruitful.

Many people who want to buy houses at Vancouver find out the Vancouver realtor who has given wide and highly impressive ads. They contact that Vancouver real estate agent over phone. This type of agents will be carrying out hundreds of deals every year so that they will be more accurate with regard to the pricing of properties. But, the drawback is that they will be too busy with their dealings so that they may not have time to attend the visitors. On the contrary, the Vancouver real estate agent who is not so busy and have very limited number of transactions can make a survey of the market and identify the property that exactly suits to his client. However, due to limited experience as well as exposure he may not be so efficient in other aspects. The one who has 5 ? 6 transactions in a year can be considered as a medium level realtor. The ideal realtor is the one who has sufficient experience in the market and have sufficient time to attend to his client?s needs. The Vancouver realtor whose number of dealings in a year is little above that of the average realtor and who is equipped with sufficient manpower will be the ideal choice.

When one is in the look out for a good negotiator for his business deal he must choose a realtor who has a long years of experience in that market. The new entrants in the field will be having better knowledge about the prevailing rules and regulations and also their computer and Internet skills might be more stronger. According to officials at the Real Estate Board, instead of going for the highly experienced as well as the least experienced one can opt for a realtor with just a few years experience.

In order to avoid the risk of relying completely on one person some people approach a few number of realtors for guidance. If we appoint one realtor who is experienced as well as capable, we can be in close co-ordination with him and can get the best attention as well as service from him. Instead, if we engage many at a time the quality of service is likely to be poor as a result of which a buyer may even miss the best opportunity to grab a home of his choice at a very favorable price. The professional realtors are able to find out very easily whether the buyer has engaged multiple realtors at a time. When the realtor comes to know that the buyer is not relying on him only he won?t have the mind to extent the best service to that buyer.

In order to ensure security for their dealings many of the buyers prefer real estate firms with larger infrastructure. However, these firms are owned and managed by independent persons or groups and the nature of service will be different in different companies. In fact, one need not bother much about the company. The individual Vancouver realtor who attends to the needs of the buyer has more significance.

The most important aspect to be considered while choosing a Vancouver real estate agent is that the buyer should feel that he can get along with the realtor easily and smoothly. After interviewing a number of real estate agents one can select the professional realtor whom he feels suitable based on professional as well as personal considerations. In such cases both the client and the service provider feel comfortable and the service provider will be able to understand clearly the requirements and preferences of his client and can easily make them as his requirements and preferences. When a realtor comes to know that his client has full trust over him and has full confidence about his abilities he will dedicate himself for the service of his client. Of course, in case the realtor fails to perform as per expectation there should not be any leniency.

For those who want to buy a house, finding out the suitable realtor is just the initial step prior to buying the property. An efficient as well as reliable realtor can ably guide us and complete the deal smoothly and in the proper way.

For more guides in regard to employing a nice real estate agent in Vancouver, or know others about shopping for real estate in Vancouver, please look up relevant website.

Source: http://www.welcometocoastcity.org/why-need-to-seek-a-good-real-estate-agent-in-vancouver.php

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Video: Gingrich: Hard to see how House GOP gets past Senate Dems

A Second Take on Meeting the Press: From an up-close look at Rachel Maddow's sneakers to an in-depth look at Jon Krakauer's latest book ? it's all fair game in our "Meet the Press: Take Two" web extra. Log on Sundays to see David Gregory's post-show conversations with leading newsmakers, authors and roundtable guests. Videos are available on-demand by 12 p.m. ET on Sundays.

Source: http://www.msnbc.msn.com/id/3032608/vp/50136300#50136300

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